Faculty & Staff
Principal investigator
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Professor; Director, Division of Respirology Jack Gauldie Boehringer Ingelheim Chair in Interstitial Lung Disease; Dr. Kolb has a special interest in ILD, in both preclinical and clinical areas. Telephone: +1 (905) 525-9140 ext. 33683
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Co-principal investigator
Jack Gauldie
PhD, FRSC, DSc
Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre
Professor
RESEARCH INTERESTS: Chronic inflammation and tissue remodeling;
molecular events that control the complex process of chronic inflammation;
molecular controls that govern the conversion of acute responses to chronic inflammatory responses.
Telephone: +1 (905) 521-2613 ext. 22640
E-mail: gauldie@mcmaster.ca
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Clinical trials team
Sarah Goodwin
BA, RRT, CCRC
Staff
Pulmonary Research Registry (PURR), Kolb Lab
Research study coordinator, PURR
Clinical trials team member, Kolb Lab
Telephone: +1 (905) 522-1155 ext. 36130
E-mail: sgoodwin@stjoes.ca
Nathan Hambly
MD, FRCPC
Medicine, Respirology
Associate Professor, Interstitial Lung Disease Program Director
Clinical interests include pulmonary hypertension, interstitial lung disease, and sarcoidosis.
RESEARCH INTERESTS: Pulmonary hypertension, interstitial lung disease, sarcoidosis and acute exacerbations of idiopathic pulmonary fibrosis
Telephone: +1 (905) 525-9140 ext. 36704
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Lab manager
Fuqin Duan
Staff
Kolb Lab
Lab manager
Telephone: +1 (905) 522-1155 ext. 32274
E-mail: duanf@mcmaster.ca
Students & Fellows
Post-doctoral fellows
Pierre-Simon Bellaye
PhD in cellular and molecular biology, Burgundy University (Dijon), France, November 2013
Kolb Lab
post-doctoral fellow
Post doctoral fellow at the Kolb Lab and the Firestone Institute for Respiratory Health
RESEARCH INTERESTS: Interested in pulmonary fibrosis and especially the role of the extracellular matrix in the lungs. Studying how abnormal extracellular matrix in cases of pulmonary fibrosis effect cells behaviour and pathogenesis.
Telephone: +1 (905) 522-1155 ext. 32274
E-mail: ps.bellaye@hotmail.fr
Chiko Shimbori
PhD in medicine, Shimane University, School of Medicine (Japan), March 2011
Kolb Lab
post-doctoral fellow
Post doctoral fellow at the Kolb Lab and the Firestone Institute for Respiratory Health
RESEARCH INTERESTS: Interested in the profibrotic microenvironment in pulmonary fibrosis. Working on multilateral projects to reveal the pathogenesis of pulmonary fibrosis in Kolb Lab using many types of pulmonary fibrosis animal models.
Telephone: +1 (905) 522-1155 ext. 32274
E-mail: chikoshimbori@gmail.com
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Graduate students
Chandak Upagupta
Kolb Lab
Graduate student
Graduate student at the Kolb Lab and the Firestone Institute for Respiratory Health
RESEARCH INTERESTS: Idiopathic pulmonary fibrosis (IPF) is a chronic disease, characterized by progressive scarring of lung tissue. To date, there are no ideal therapies for IPF, with the ones currently in use only being able to reduce the progression of the disease. Key components contributing to the development and progression of IPF are the accumulation of extracellular matrix (ECM), and the persistence of myofibroblasts; the cells responsible for ECM deposition. The effect of ECM properties (composition & stiffness) on the phenotype of pulmonary cells is yet to be fully elucidated. We developed a whole rodent lung decellularization protocol for complete elimination of cells, allowing for reseeding with particular cell types to investigate the impact of lung ECM on cells’ behaviour. The decellularized lung will be installed in a lung bioreactor, which provides constant vasculature perfusion and positive ventilation for the reseeded decellularized lung, mimicking the 3-D lung environment. We propose to culture human induced pluripotent stem cells (IPSc) on decellularized lungs (control and fibrotic) to investigate the differentiation of IPSc. This project will shed some light on ECM driven cell differentiation, and could potentially further the understanding of Idiopathic Pulmonary Fibrosis.
Telephone: +1 (905) 522-1155 ext. 32274
E-mail: upagupc@mcmaster.ca
Undergraduate Students
- Mengyu (Phoebe) Zheng (co-op)
- Cindy Yu (volunteer)
- Jae (Greg) Byun (volunteer)